Working group Sperling
Department of General, Visceral and Pediatric Surgery
Locoregional tumortherapy
Our research focuses on different possibilities for application of locoregional tumor therapy. Hepatic-arterial infusion (HAI) and transarterial chemoembolization (TACE) are used as locoregional therapeutic modalities for treatment of colorectal liver metastases. Analysis of inhibitory effect of diverse chemotherapeutic agents on metastatic tumor growth and their impact on the hepatic microcirculation is perfomed. Different imaging tools like intravital microscopy and 3D-ultrasound as well as histologic and immunohistochemical stainings are used.
Intraoperative Imaging - Image Guided Surgery
Modern intraoperative techniques of visualization are increasingly applied in general and visceral surgery. Therefor the working group focuses on the application of Intraoperative Near-Infrared fluorescence imaging. With or without the application of specific fluorescent agents physiologic processes as well as specific anatomical structures can be visualized intraoperatively. Beside tissue-perfusion-measurement, differentiation between normal and tumor tissue for exact definition of the tumor margin is performed.
Cooperation partners
- Prof. Dr. med. Michael D. Menger
Institute for Clinical and Experimental Surgery, University of Saarland, Homburg, Germany - Prof. Frauke Alves
Max-Planck-Institute for Experimental Medicine, Göttingen, Germany - a.o. Univ. Prof. Mag. Dr. Martin Czejka
- Abteilung für klinische Pharmazie und Diagnostik, Universität Wien, Österreich
Publications
- Intraoperative multidimensional visualization. [Article in German]
Sperling J, Kauffels A, Grade M, Alves F, Kühn P, Ghadimi BM. Chirurg. 2016;87(12):1015-1024.
Tumour growth of colorectal rat liver metastases is inhibited by hepatic arterial infusion of the mTOR-inhibitor temsirolimus after portal branch ligation.
Sperling J, Ziemann C, Gittler A, Benz-Weißer A, Menger MD, Kollmar O. Clin Exp Metastasis. 2015;32(4):313-21. - Hepatic arterial infusion of temsirolimus inhibits tumor growth of colorectal rat liver metastases even after a growth stimulating procedure like liver resection.
Sperling J, Ziemann C, Gittler A, Benz-Weißer A, Menger MD, Kollmar O. J Surg Res. 2013;185(2):587-94. - Hepatic arterial infusion but not systemic application of cetuximab in combination with oxaliplatin significantly reduces growth of CC531 colorectal rat liver metastases.
Sperling J, Schäfer T, Benz-Weißer A, Ziemann C, Scheuer C, Kollmar O, Schilling MK, Menger MD. Int J Colorectal Dis. 2013 Apr;28(4):555-62. - Hepatic arterial infusion of bevacizumab in combination with oxaliplatin reduces tumor growth in a rat model of colorectal liver metastases.
Sperling J, Schäfer T, Ziemann C, Benz-Weißer A, Kollmar O, Schilling MK, Menger MD. Clin Exp Metastasis. 2012;29(2):91-9. Epub 2011 Nov 4.