Working group Sperling

Department of General, Visceral and Pediatric Surgery

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Locoregional tumortherapy

Our research focuses on different possibilities for application of locoregional tumor therapy. Hepatic-arterial infusion (HAI) and transarterial chemoembolization (TACE) are used as locoregional therapeutic modalities for treatment of colorectal liver metastases. Analysis of inhibitory effect of diverse chemotherapeutic agents on metastatic tumor growth and their impact on the hepatic microcirculation is perfomed. Different imaging tools like intravital microscopy and 3D-ultrasound as well as histologic and immunohistochemical stainings are used.

Intraoperative Imaging - Image Guided Surgery

Modern intraoperative techniques of visualization are increasingly applied in general and visceral surgery. Therefor the working group focuses on the application of Intraoperative Near-Infrared fluorescence imaging. With or without the application of specific fluorescent agents physiologic processes as well as specific anatomical structures can be visualized intraoperatively. Beside tissue-perfusion-measurement, differentiation between normal and tumor tissue for exact definition of the tumor margin is performed.

Cooperation partners

  • Prof. Dr. med. Michael D. Menger
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg, Germany
  • Prof. Frauke Alves
    Max-Planck-Institute for Experimental Medicine, Göttingen, Germany
  • a.o. Univ. Prof. Mag. Dr. Martin Czejka
  • Abteilung für klinische Pharmazie und Diagnostik, Universität Wien, Österreich

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